diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index 082a17b..41c9600 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -523,6 +523,68 @@ NODE_CLASS_MAPPINGS[get_id()] = DynamicDupNode
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def _assert_namespace_mapping_replacement_duplicate_skips_static_node(self, replacement, pack_id):
+        source_a = '''
+class StaticDupNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "DupNode": StaticDupNode,
+}
+'''
+        source_b = f'''
+class DynamicDupNode:
+    RETURN_TYPES = ("MASK",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {{
+            "required": {{
+                "mask": ("MASK",),
+            }},
+        }}
+
+
+{replacement}
+'''
+        result = self._extract_two_sources(source_a, source_b, pack_id)
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_duplicate_node_id_from_globals_update_mapping_replacement_skips_static_node(self):
+        self._assert_namespace_mapping_replacement_duplicate_skips_static_node(
+            'globals().update(NODE_CLASS_MAPPINGS={"DupNode": DynamicDupNode})',
+            "globals-update-replacement-duplicate-node-pack",
+        )
+
+    def test_duplicate_node_id_from_globals_dunder_setitem_mapping_replacement_skips_static_node(self):
+        self._assert_namespace_mapping_replacement_duplicate_skips_static_node(
+            'globals().__setitem__("NODE_CLASS_MAPPINGS", {"DupNode": DynamicDupNode})',
+            "globals-dunder-setitem-replacement-duplicate-node-pack",
+        )
+
+    def test_duplicate_node_id_from_namespace_alias_update_mapping_replacement_skips_static_node(self):
+        self._assert_namespace_mapping_replacement_duplicate_skips_static_node(
+            'ns = globals()\nns.update(NODE_CLASS_MAPPINGS={"DupNode": DynamicDupNode})',
+            "namespace-alias-update-replacement-duplicate-node-pack",
+        )
+
+    def test_duplicate_node_id_from_namespace_alias_dunder_setitem_mapping_replacement_skips_static_node(self):
+        self._assert_namespace_mapping_replacement_duplicate_skips_static_node(
+            'ns = globals()\nns.__setitem__("NODE_CLASS_MAPPINGS", {"DupNode": DynamicDupNode})',
+            "namespace-alias-dunder-setitem-replacement-duplicate-node-pack",
+        )
+
     def test_unsupported_reassignment_invalidates_static_env_value(self):
         source = '''
 def build_inputs():
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index 5a52d1b..c7aa565 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -1856,6 +1856,7 @@ def _namespace_alias_mutation_target_names(stmt, aliases):
                 names.update(_namespace_alias_target_names(target, aliases))
 
         def visit_Call(self, node):
+            names.update(_namespace_mutating_call_target_names(node))
             if isinstance(node.func, ast.Attribute):
                 if isinstance(node.func.value, ast.Name) and node.func.value.id in aliases:
                     if node.func.attr in _NAMESPACE_DUNDER_MUTATORS:
@@ -2302,6 +2303,9 @@ def _node_class_mapping_keys(tree):
         if mutation_keys is _INVALID:
             return _INVALID
         keys.update(mutation_keys)
+        namespace_mutations = _namespace_alias_mutation_target_names(stmt, namespace_aliases)
+        if _name_invalidated_by("NODE_CLASS_MAPPINGS", namespace_mutations):
+            return _INVALID
         _apply_module_stmt_to_env(stmt, env, class_bindings)
         _update_module_dict_aliases(
             stmt,