diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index 8f6f7cc..4be5680 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -359,6 +359,61 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_annotated_alias_mutation_invalidates_static_source_value(self):
+        source = '''
+INPUTS = {
+    "required": {
+        "image": ("IMAGE",),
+    },
+}
+ALIAS: dict = INPUTS
+ALIAS.clear()
+
+
+class AnnotatedAliasMutatedInputNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return INPUTS
+
+
+NODE_CLASS_MAPPINGS = {
+    "AnnotatedAliasMutatedInputNode": AnnotatedAliasMutatedInputNode,
+}
+'''
+        result = self._extract_source(source, "annotated-alias-mutated-input-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_wildcard_import_invalidates_static_env_values(self):
+        source = '''
+INPUTS = {
+    "required": {
+        "image": ("IMAGE",),
+    },
+}
+from something import *
+
+
+class WildcardImportInputNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return INPUTS
+
+
+NODE_CLASS_MAPPINGS = {
+    "WildcardImportInputNode": WildcardImportInputNode,
+}
+'''
+        result = self._extract_source(source, "wildcard-import-input-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_annotated_reassignment_invalidates_static_env_value(self):
         source = '''
 def build_inputs():
@@ -659,6 +714,55 @@ NODE_CLASS_MAPPINGS.clear()
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_annotated_alias_mutation_invalidates_static_node_mapping(self):
+        source = '''
+class AnnotatedAliasMutatedMappingNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "AnnotatedAliasMutatedMappingNode": AnnotatedAliasMutatedMappingNode,
+}
+ALIAS: dict = NODE_CLASS_MAPPINGS
+ALIAS.clear()
+'''
+        result = self._extract_source(source, "annotated-alias-mutated-mapping-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_wildcard_import_invalidates_static_node_mapping(self):
+        source = '''
+class WildcardImportMappingNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "WildcardImportMappingNode": WildcardImportMappingNode,
+}
+from something import *
+'''
+        result = self._extract_source(source, "wildcard-import-mapping-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_dynamic_display_mapping_reassignment_falls_back_to_node_type(self):
         source = '''
 def build_displays():
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index 417ff07..cf623ea 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -148,6 +148,10 @@ def _bound_names(stmt):
     return names
 
 
+def _has_wildcard_import(stmt):
+    return isinstance(stmt, ast.ImportFrom) and any(alias.name == "*" for alias in stmt.names)
+
+
 def _assignment_target_names(stmt):
     if isinstance(stmt, ast.Assign):
         names = set()
@@ -276,6 +280,14 @@ def _collect_module_env(tree):
                 continue
             if isinstance(stmt.target, ast.Name):
                 name = stmt.target.id
+                if (
+                    isinstance(stmt.value, ast.Name)
+                    and stmt.value.id in env
+                    and _is_mutable_static_value(env[stmt.value.id])
+                ):
+                    env.pop(stmt.value.id, None)
+                    env.pop(name, None)
+                    continue
                 try:
                     env[name] = _literal(stmt.value, env)
                 except UnsupportedStaticExpression:
@@ -302,6 +314,9 @@ def _collect_module_env(tree):
             for name in _assigned_names_in_control_flow(stmt):
                 env.pop(name, None)
             continue
+        if _has_wildcard_import(stmt):
+            env.clear()
+            continue
         for name in _bound_names(stmt):
             env.pop(name, None)
     return env
@@ -425,6 +440,8 @@ def _final_module_dict(tree, env, name, value_converter):
             continue
         if isinstance(stmt, ast.AnnAssign):
             if not _name_is_assigned(stmt, name):
+                if isinstance(stmt.value, ast.Name) and stmt.value.id == name:
+                    value = _INVALID
                 continue
             if isinstance(stmt.target, ast.Name) and stmt.value is not None:
                 try:
@@ -452,6 +469,9 @@ def _final_module_dict(tree, env, name, value_converter):
             if name in _assigned_names_in_control_flow(stmt):
                 value = _INVALID
             continue
+        if _has_wildcard_import(stmt):
+            value = _INVALID
+            continue
         if name in _bound_names(stmt):
             value = _INVALID
     if value in (_MISSING, _INVALID):