diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index 8328fa2..c47b183 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -1486,6 +1486,31 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_return_types_chained_alias_mutation_skips_node(self):
+        source = '''
+class ChainedAliasMutatedReturnTypesNode:
+    RETURN_TYPES = ["IMAGE"]
+    A = B = RETURN_TYPES
+    A.append("MASK")
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "ChainedAliasMutatedReturnTypesNode": ChainedAliasMutatedReturnTypesNode,
+}
+'''
+        result = self._extract_source(source, "chained-alias-mutated-return-types-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_return_types_unpacked_alias_mutation_skips_node(self):
         source = '''
 class UnpackedAliasMutatedReturnTypesNode:
@@ -2446,6 +2471,31 @@ Alias.RETURN_TYPES = ("MASK",)
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_module_class_chained_alias_patch_after_mapping_skips_node(self):
+        source = '''
+class ChainedAliasPatchedNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "ChainedAliasPatchedNode": ChainedAliasPatchedNode,
+}
+A = B = ChainedAliasPatchedNode
+A.RETURN_TYPES = ("MASK",)
+'''
+        result = self._extract_source(source, "chained-alias-patched-node-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_module_class_starred_alias_patch_after_mapping_skips_node(self):
         source = '''
 class StarredAliasPatchedNode:
@@ -2622,6 +2672,32 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_module_class_attribute_chained_alias_mutation_skips_node(self):
+        source = '''
+class ChainedAttributeAliasNode:
+    RETURN_TYPES = ["IMAGE"]
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+A = B = ChainedAttributeAliasNode.RETURN_TYPES
+A.append("MASK")
+
+NODE_CLASS_MAPPINGS = {
+    "ChainedAttributeAliasNode": ChainedAttributeAliasNode,
+}
+'''
+        result = self._extract_source(source, "chained-attribute-alias-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_module_class_attribute_tuple_alias_mutation_skips_node(self):
         source = '''
 class TupleAttributeAliasNode:
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index 1c6fcea..b485400 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -1009,6 +1009,18 @@ def _class_attr(cls, name, env):
             value = _INVALID
         if isinstance(stmt, ast.Assign):
             target_names = _assignment_target_names(stmt)
+            if len(stmt.targets) > 1 and _class_attr_alias_sources(stmt.value, name, aliases):
+                target_aliases = []
+                for target in stmt.targets:
+                    target_name = _alias_target_name(target)
+                    if target_name is None:
+                        value = _INVALID
+                        target_aliases = []
+                        break
+                    target_aliases.append(target_name)
+                aliases.update(alias for alias in target_aliases if alias != name)
+                if name not in target_names:
+                    continue
             if (
                 len(stmt.targets) == 1
                 and isinstance(stmt.targets[0], ast.Name)
@@ -1290,6 +1302,13 @@ def _update_class_aliases(stmt, class_aliases, class_bindings):
         sources = _class_alias_sources(stmt.value, class_aliases, class_bindings)
         if sources:
             class_aliases[stmt.targets[0].id] = sources
+    elif isinstance(stmt, ast.Assign) and len(stmt.targets) > 1:
+        sources = _class_alias_sources(stmt.value, class_aliases, class_bindings)
+        if sources:
+            for target in stmt.targets:
+                target_name = _alias_target_name(target)
+                if target_name is not None:
+                    class_aliases[target_name] = sources
     elif isinstance(stmt, ast.Assign) and len(stmt.targets) == 1:
         _update_class_alias_from_unpack(stmt.targets[0], stmt.value, class_aliases, class_bindings)
     elif isinstance(stmt, ast.AnnAssign) and isinstance(stmt.target, ast.Name) and stmt.value is not None:
@@ -1387,6 +1406,18 @@ def _update_class_attribute_aliases(stmt, class_attribute_aliases, class_aliases
         )
         if sources:
             class_attribute_aliases[stmt.targets[0].id] = sources
+    elif isinstance(stmt, ast.Assign) and len(stmt.targets) > 1:
+        sources = _class_attribute_alias_sources(
+            stmt.value,
+            class_attribute_aliases,
+            class_aliases,
+            class_bindings,
+        )
+        if sources:
+            for target in stmt.targets:
+                target_name = _alias_target_name(target)
+                if target_name is not None:
+                    class_attribute_aliases[target_name] = sources
     elif isinstance(stmt, ast.Assign) and len(stmt.targets) == 1:
         _update_class_attribute_alias_from_unpack(
             stmt.targets[0],