diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index f7c0676..8b94935 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -1659,6 +1659,107 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_class_body_locals_alias_return_types_setitem_skips_node(self):
+        source = '''
+class LocalsAliasReturnTypesNode:
+    RETURN_TYPES = ("IMAGE",)
+    ns = locals()
+    ns["RETURN_TYPES"] = ("MASK",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "LocalsAliasReturnTypesNode": LocalsAliasReturnTypesNode,
+}
+'''
+        result = self._extract_source(source, "locals-alias-return-types-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_class_body_vars_alias_return_types_update_skips_node(self):
+        source = '''
+class VarsAliasReturnTypesNode:
+    RETURN_TYPES = ("IMAGE",)
+    ns = vars()
+    ns.update(RETURN_TYPES=("MASK",))
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "VarsAliasReturnTypesNode": VarsAliasReturnTypesNode,
+}
+'''
+        result = self._extract_source(source, "vars-alias-return-types-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_class_body_chained_namespace_alias_return_types_setitem_skips_node(self):
+        source = '''
+class ChainedNamespaceAliasReturnTypesNode:
+    RETURN_TYPES = ("IMAGE",)
+    ns = other = locals()
+    other["RETURN_TYPES"] = ("MASK",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "ChainedNamespaceAliasReturnTypesNode": ChainedNamespaceAliasReturnTypesNode,
+}
+'''
+        result = self._extract_source(source, "chained-namespace-alias-return-types-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_class_body_namespace_alias_return_names_update_skips_node(self):
+        source = '''
+class NamespaceAliasReturnNamesNode:
+    RETURN_TYPES = ("IMAGE",)
+    RETURN_NAMES = ["image"]
+    ns = locals()
+    ns.update(RETURN_NAMES=["mask"])
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "NamespaceAliasReturnNamesNode": NamespaceAliasReturnNamesNode,
+}
+'''
+        result = self._extract_source(source, "namespace-alias-return-names-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_except_handler_binding_to_return_types_skips_node(self):
         source = '''
 class ExceptHandlerBoundReturnTypesNode:
@@ -4234,6 +4335,40 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_class_body_namespace_alias_input_types_patch_skips_node(self):
+        source = '''
+def build_inputs(cls):
+    return {
+        "required": {
+            "mask": ("MASK",),
+        },
+    }
+
+
+class NamespaceAliasInputTypesPatchNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+    ns = locals()
+    ns["INPUT_TYPES"] = build_inputs
+
+
+NODE_CLASS_MAPPINGS = {
+    "NamespaceAliasInputTypesPatchNode": NamespaceAliasInputTypesPatchNode,
+}
+'''
+        result = self._extract_source(source, "namespace-alias-input-types-patch-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_input_types_alias_observed_by_arbitrary_call_skips_node(self):
         source = '''
 class AliasObservedInputTypesNode:
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index 31561f8..d146b2e 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -933,6 +933,15 @@ def _class_body_module_mutation_names(cls):
     return names
 
 
+def _class_body_namespace_mutation_names(cls):
+    names = set()
+    namespace_aliases = set()
+    for stmt in cls.body:
+        names.update(_namespace_alias_mutation_target_names(stmt, namespace_aliases))
+        _update_namespace_aliases(stmt, namespace_aliases)
+    return names
+
+
 def _apply_module_stmt_to_env(stmt, env, class_bindings=None):
     names = _mutating_call_target_names(stmt)
     if isinstance(stmt, ast.ClassDef):
@@ -1165,6 +1174,9 @@ def _update_input_types_aliases_from_unpack(target, value, aliases):
 def _class_attr(cls, name, env):
     value = _MISSING
     aliases = set()
+    namespace_mutations = _class_body_namespace_mutation_names(cls)
+    if _name_invalidated_by(name, namespace_mutations):
+        return _INVALID
     for stmt in cls.body:
         mutating_targets = _mutating_call_target_names(stmt)
         observed_targets = _arbitrary_call_observed_names(stmt)
@@ -1295,6 +1307,9 @@ def _input_types(cls, env, decorator_env):
     value = _MISSING
     aliases = set()
     classmethod_shadowed = "classmethod" in decorator_env
+    namespace_mutations = _class_body_namespace_mutation_names(cls)
+    if _name_invalidated_by("INPUT_TYPES", namespace_mutations):
+        return None
     for stmt in cls.body:
         mutating_targets = _mutating_call_target_names(stmt)
         observed_targets = _arbitrary_call_observed_names(stmt)