diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index 72f13d3..f25107d 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -1288,6 +1288,55 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_getattr_method_mutation_to_return_types_skips_node(self):
+        source = '''
+class GetattrMethodMutatedReturnTypesNode:
+    RETURN_TYPES = ["IMAGE"]
+    getattr(RETURN_TYPES, "clear")()
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "GetattrMethodMutatedReturnTypesNode": GetattrMethodMutatedReturnTypesNode,
+}
+'''
+        result = self._extract_source(source, "getattr-method-mutated-return-types-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_getattr_method_mutation_to_return_names_skips_node(self):
+        source = '''
+class GetattrMethodMutatedReturnNamesNode:
+    RETURN_TYPES = ("IMAGE",)
+    RETURN_NAMES = ["image"]
+    getattr(RETURN_NAMES, "clear")()
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "GetattrMethodMutatedReturnNamesNode": GetattrMethodMutatedReturnNamesNode,
+}
+'''
+        result = self._extract_source(source, "getattr-method-mutated-return-names-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_except_handler_binding_to_return_types_skips_node(self):
         source = '''
 class ExceptHandlerBoundReturnTypesNode:
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index 5ebca0f..ff85e1d 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -150,6 +150,23 @@ def _getattr_signature_target_names(node):
     return {name}
 
 
+def _getattr_mutating_method_target_names(node):
+    if not isinstance(node, ast.Call):
+        return set()
+    if not isinstance(node.func, ast.Call):
+        return set()
+    getattr_call = node.func
+    if not isinstance(getattr_call.func, ast.Name) or getattr_call.func.id != "getattr":
+        return set()
+    if len(getattr_call.args) < 2:
+        return set()
+    method = getattr_call.args[1]
+    if isinstance(method, ast.Constant) and isinstance(method.value, str):
+        if method.value not in _MUTATING_METHODS:
+            return set()
+    return _target_names(getattr_call.args[0])
+
+
 def _attribute_target_base_names(target):
     if isinstance(target, ast.Attribute):
         name = _root_name(target.value)
@@ -241,6 +258,7 @@ def _class_attribute_mutation_target_names(stmt):
 
         def visit_Call(self, node):
             names.update(_setattr_delattr_target_names(node))
+            names.update(_getattr_mutating_method_target_names(node))
             if isinstance(node.func, ast.Attribute) and node.func.attr in _MUTATING_METHODS:
                 names.update(_attribute_target_base_names(node.func.value))
             self.generic_visit(node)
@@ -409,6 +427,7 @@ def _mutating_call_target_names(stmt):
 
         def visit_Call(self, node):
             names.update(_setattr_delattr_target_names(node))
+            names.update(_getattr_mutating_method_target_names(node))
             if isinstance(node.func, ast.Attribute) and node.func.attr in _MUTATING_METHODS:
                 names.update(_target_names(node.func.value))
             self.generic_visit(node)