diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index 4e21db8..f2e138a 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -999,6 +999,45 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({"image": "IMAGE"}, result["nodes"]["RuntimeBodyMutatedInputEnvNode"]["inputs"])
         self.assertEqual("ok", result["pack"]["status"])
 
+    def test_class_body_global_assignment_invalidates_static_input_env(self):
+        source = '''
+INPUTS = {
+    "required": {
+        "image": ("IMAGE",),
+    },
+}
+
+
+def build_inputs():
+    return {
+        "required": {
+            "mask": ("MASK",),
+        },
+    }
+
+
+class MutatesModuleAtDefinition:
+    global INPUTS
+    INPUTS = build_inputs()
+
+
+class ClassGlobalMutatedInputEnvNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return INPUTS
+
+
+NODE_CLASS_MAPPINGS = {
+    "ClassGlobalMutatedInputEnvNode": ClassGlobalMutatedInputEnvNode,
+}
+'''
+        result = self._extract_source(source, "class-global-mutated-input-env-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_nested_mutable_env_literal_skips_static_node(self):
         source = '''
 REQ = {
@@ -1303,6 +1342,32 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_input_types_with_duplicate_required_optional_name_skips_node(self):
+        source = '''
+class DuplicateInputNameNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "x": ("IMAGE",),
+            },
+            "optional": {
+                "x": ("MASK",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "DuplicateInputNameNode": DuplicateInputNameNode,
+}
+'''
+        result = self._extract_source(source, "duplicate-input-name-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_input_types_with_non_string_input_name_skips_node(self):
         source = '''
 class NonStringInputNameNode:
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index b3a6e02..45d953c 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -800,8 +800,140 @@ def _is_trivially_safe_class_def(stmt):
     )
 
 
+def _namespace_assignment_target_names(target):
+    name = _namespace_subscript_name(target)
+    if name is not None:
+        return {name}
+    if isinstance(target, ast.Attribute):
+        return _namespace_assignment_target_names(target.value)
+    if isinstance(target, ast.Subscript):
+        return _namespace_assignment_target_names(target.value)
+    if isinstance(target, (ast.List, ast.Tuple)):
+        names = set()
+        for item in target.elts:
+            names.update(_namespace_assignment_target_names(item))
+        return names
+    if isinstance(target, ast.Starred):
+        return _namespace_assignment_target_names(target.value)
+    return set()
+
+
+def _class_body_global_names(cls):
+    names = set()
+
+    class GlobalVisitor(ast.NodeVisitor):
+        def visit_FunctionDef(self, node):
+            return None
+
+        def visit_AsyncFunctionDef(self, node):
+            return None
+
+        def visit_ClassDef(self, node):
+            return None
+
+        def visit_Global(self, node):
+            names.update(node.names)
+
+    for stmt in cls.body:
+        GlobalVisitor().visit(stmt)
+    return names
+
+
+def _class_body_module_mutation_names(cls):
+    global_names = _class_body_global_names(cls)
+    names = set()
+
+    def add_assignment_targets(stmt):
+        names.update(_assignment_target_names(stmt).intersection(global_names))
+        if isinstance(stmt, ast.Assign):
+            for target in stmt.targets:
+                names.update(_namespace_assignment_target_names(target))
+        elif isinstance(stmt, (ast.AnnAssign, ast.AugAssign)):
+            names.update(_namespace_assignment_target_names(stmt.target))
+        elif isinstance(stmt, (ast.For, ast.AsyncFor)):
+            names.update(_namespace_assignment_target_names(stmt.target))
+
+    class ClassBodyMutationVisitor(ast.NodeVisitor):
+        def _visit_function_definition_expressions(self, node):
+            names.update(_mutating_call_target_names(node))
+            names.update(_namespace_alias_mutation_target_names(node, set()))
+
+        def visit_FunctionDef(self, node):
+            self._visit_function_definition_expressions(node)
+
+        def visit_AsyncFunctionDef(self, node):
+            self._visit_function_definition_expressions(node)
+
+        def visit_ClassDef(self, node):
+            for decorator in node.decorator_list:
+                self.visit(decorator)
+            for base in node.bases:
+                self.visit(base)
+            for keyword in node.keywords:
+                self.visit(keyword.value)
+            for type_param in getattr(node, "type_params", ()):
+                self.visit(type_param)
+            names.update(_class_body_module_mutation_names(node))
+
+        def visit_Assign(self, node):
+            add_assignment_targets(node)
+            self.visit(node.value)
+
+        def visit_AnnAssign(self, node):
+            add_assignment_targets(node)
+            if node.value is not None:
+                self.visit(node.value)
+
+        def visit_AugAssign(self, node):
+            add_assignment_targets(node)
+            self.visit(node.value)
+
+        def visit_Delete(self, node):
+            names.update(_delete_target_names(node).intersection(global_names))
+            for target in node.targets:
+                names.update(_namespace_assignment_target_names(target))
+
+        def visit_For(self, node):
+            add_assignment_targets(node)
+            self.generic_visit(node)
+
+        def visit_AsyncFor(self, node):
+            add_assignment_targets(node)
+            self.generic_visit(node)
+
+        def visit_With(self, node):
+            for item in node.items:
+                if item.optional_vars is not None:
+                    names.update(_target_names(item.optional_vars).intersection(global_names))
+                    names.update(_namespace_assignment_target_names(item.optional_vars))
+            self.generic_visit(node)
+
+        def visit_AsyncWith(self, node):
+            for item in node.items:
+                if item.optional_vars is not None:
+                    names.update(_target_names(item.optional_vars).intersection(global_names))
+                    names.update(_namespace_assignment_target_names(item.optional_vars))
+            self.generic_visit(node)
+
+        def visit_Import(self, node):
+            names.update(_bound_names(node).intersection(global_names))
+
+        def visit_ImportFrom(self, node):
+            names.update(_bound_names(node).intersection(global_names))
+
+        def visit_Call(self, node):
+            names.update(_namespace_mutating_call_target_names(node))
+            self.generic_visit(node)
+
+    for stmt in cls.body:
+        ClassBodyMutationVisitor().visit(stmt)
+    return names
+
+
 def _apply_module_stmt_to_env(stmt, env, class_bindings=None):
     names = _mutating_call_target_names(stmt)
+    if isinstance(stmt, ast.ClassDef):
+        names.update(_class_body_module_mutation_names(stmt))
     if _DYNAMIC_NAMESPACE_MUTATION in names:
         env.clear()
         if class_bindings is not None:
@@ -1721,6 +1853,9 @@ def _final_module_dict(tree, name, value_converter, value_invalidated_by_names=N
         _update_namespace_aliases(stmt, namespace_aliases)
 
     for stmt in tree.body:
+        class_body_module_mutations = (
+            _class_body_module_mutation_names(stmt) if isinstance(stmt, ast.ClassDef) else set()
+        )
         class_attr_names = _module_class_attribute_invalidated_names(stmt, class_aliases, class_attribute_aliases)
         if (
             value not in (_MISSING, _INVALID)
@@ -1732,6 +1867,9 @@ def _final_module_dict(tree, name, value_converter, value_invalidated_by_names=N
         if _name_invalidated_by(name, _mutating_call_target_names(stmt)):
             value = _INVALID
             sticky_invalid = True
+        if _name_invalidated_by(name, class_body_module_mutations):
+            value = _INVALID
+            sticky_invalid = True
         if _name_invalidated_by(name, _arbitrary_call_observed_names(stmt)):
             value = _INVALID
             sticky_invalid = True
@@ -1905,6 +2043,8 @@ def _signature_from_class(node_type, cls, display, pack_meta, class_env, input_e
         for name, spec in values.items():
             if not isinstance(name, str):
                 return None
+            if name in inputs:
+                return None
             input_type = normalise_input_spec(spec)
             if input_type is None:
                 return None