diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index eeca5c1..2f60eeb 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -2532,6 +2532,55 @@ RET.clear()
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_module_class_attribute_arbitrary_call_after_mapping_skips_node(self):
+        source = '''
+class ObserveAttributeCallNode:
+    RETURN_TYPES = ["IMAGE"]
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "ObserveAttributeCallNode": ObserveAttributeCallNode,
+}
+mutate(ObserveAttributeCallNode.RETURN_TYPES)
+'''
+        result = self._extract_source(source, "observe-attribute-call-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_module_class_attribute_alias_arbitrary_call_after_mapping_skips_node(self):
+        source = '''
+class ObserveAttributeAliasCallNode:
+    RETURN_TYPES = ["IMAGE"]
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "ObserveAttributeAliasCallNode": ObserveAttributeAliasCallNode,
+}
+RET = ObserveAttributeAliasCallNode.RETURN_TYPES
+mutate(RET)
+'''
+        result = self._extract_source(source, "observe-attribute-alias-call-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_getattr_return_types_mutation_after_mapping_skips_node(self):
         source = '''
 class GetattrReturnTypesNode:
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index 85bd45e..db8986a 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -323,6 +323,72 @@ def _class_attribute_mutation_target_names(stmt):
     return names
 
 
+def _signature_attribute_reference_names(node):
+    names = set()
+
+    class SignatureAttributeReferenceVisitor(ast.NodeVisitor):
+        def visit_Attribute(self, child):
+            if child.attr in _CLASS_SIGNATURE_ATTRS:
+                name = _root_name(child.value)
+                if name is not None:
+                    names.add(name)
+            self.generic_visit(child)
+
+        def visit_Call(self, child):
+            names.update(_getattr_signature_target_names(child))
+            self.generic_visit(child)
+
+    SignatureAttributeReferenceVisitor().visit(node)
+    return names
+
+
+def _class_attribute_observed_target_names(stmt):
+    names = set()
+
+    class AttributeObservationVisitor(ast.NodeVisitor):
+        def _visit_function_definition_expressions(self, node):
+            for decorator in node.decorator_list:
+                self.visit(decorator)
+            self.visit(node.args)
+            if node.returns is not None:
+                self.visit(node.returns)
+            for type_param in getattr(node, "type_params", ()):
+                self.visit(type_param)
+
+        def visit_FunctionDef(self, node):
+            self._visit_function_definition_expressions(node)
+
+        def visit_AsyncFunctionDef(self, node):
+            self._visit_function_definition_expressions(node)
+
+        def visit_ClassDef(self, node):
+            for decorator in node.decorator_list:
+                self.visit(decorator)
+            for base in node.bases:
+                self.visit(base)
+            for keyword in node.keywords:
+                self.visit(keyword.value)
+            for type_param in getattr(node, "type_params", ()):
+                self.visit(type_param)
+            for child in node.body:
+                self.visit(child)
+
+        def visit_Lambda(self, node):
+            self.visit(node.args)
+
+        def visit_Call(self, node):
+            if isinstance(node.func, ast.Attribute):
+                names.update(_signature_attribute_reference_names(node.func.value))
+            for arg in node.args:
+                names.update(_signature_attribute_reference_names(arg))
+            for keyword in node.keywords:
+                names.update(_signature_attribute_reference_names(keyword.value))
+            self.generic_visit(node)
+
+    AttributeObservationVisitor().visit(stmt)
+    return names
+
+
 def _pattern_bound_names(pattern):
     names = set()
     if isinstance(pattern, ast.MatchAs):
@@ -1179,6 +1245,7 @@ def _update_class_attribute_alias_from_unpack(
 def _class_attribute_alias_invalidated_names(stmt, class_attribute_aliases):
     names = (
         _mutating_call_target_names(stmt)
+        | _arbitrary_call_observed_names(stmt)
         | _assignment_target_names(stmt)
         | _delete_target_names(stmt)
         | _bound_names(stmt)
@@ -1227,6 +1294,12 @@ def _module_class_attribute_invalidated_names(stmt, class_aliases, class_attribu
         _class_attribute_mutation_target_names(stmt),
         class_aliases,
     )
+    names.update(
+        _expanded_class_attribute_names(
+            _class_attribute_observed_target_names(stmt),
+            class_aliases,
+        )
+    )
     names.update(_class_attribute_alias_invalidated_names(stmt, class_attribute_aliases))
     return names