diff --git a/tests/test_generate_popular_node_signatures.py b/tests/test_generate_popular_node_signatures.py
index 674a1b6..b0f045c 100644
--- a/tests/test_generate_popular_node_signatures.py
+++ b/tests/test_generate_popular_node_signatures.py
@@ -2978,6 +2978,56 @@ globals().update(NODE_CLASS_MAPPINGS={})
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_globals_alias_subscript_assignment_invalidates_static_node_mapping(self):
+        source = '''
+class GlobalAliasSubscriptAssignmentNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "GlobalAliasSubscriptAssignmentNode": GlobalAliasSubscriptAssignmentNode,
+}
+G = globals()
+G["NODE_CLASS_MAPPINGS"] = {}
+'''
+        result = self._extract_source(source, "global-alias-subscript-assignment-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_globals_alias_update_invalidates_static_node_mapping(self):
+        source = '''
+class GlobalAliasUpdateNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "GlobalAliasUpdateNode": GlobalAliasUpdateNode,
+}
+G = globals()
+G.update(NODE_CLASS_MAPPINGS={})
+'''
+        result = self._extract_source(source, "global-alias-update-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_arbitrary_call_invalidates_static_node_mapping(self):
         source = '''
 class ArbitraryCallMappingNode:
@@ -3493,6 +3543,52 @@ NODE_CLASS_MAPPINGS = {
         self.assertEqual({}, result["nodes"])
         self.assertEqual("no_static_nodes", result["pack"]["status"])
 
+    def test_input_types_default_observed_by_arbitrary_call_skips_node(self):
+        source = '''
+class DefaultObservedInputTypesNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls, value=observe(INPUT_TYPES)):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "DefaultObservedInputTypesNode": DefaultObservedInputTypesNode,
+}
+'''
+        result = self._extract_source(source, "default-observed-input-types-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
+    def test_input_types_return_annotation_observed_by_arbitrary_call_skips_node(self):
+        source = '''
+class AnnotationObservedInputTypesNode:
+    RETURN_TYPES = ("IMAGE",)
+
+    @classmethod
+    def INPUT_TYPES(cls) -> observe(INPUT_TYPES):
+        return {
+            "required": {
+                "image": ("IMAGE",),
+            },
+        }
+
+
+NODE_CLASS_MAPPINGS = {
+    "AnnotationObservedInputTypesNode": AnnotationObservedInputTypesNode,
+}
+'''
+        result = self._extract_source(source, "annotation-observed-input-types-pack")
+
+        self.assertEqual({}, result["nodes"])
+        self.assertEqual("no_static_nodes", result["pack"]["status"])
+
     def test_write_artifact_is_deterministic(self):
         with tempfile.TemporaryDirectory() as tmp:
             out_one = Path(tmp, "one.json")
diff --git a/tools/generate_popular_node_signatures.py b/tools/generate_popular_node_signatures.py
index cb75fbf..78c112a 100644
--- a/tools/generate_popular_node_signatures.py
+++ b/tools/generate_popular_node_signatures.py
@@ -142,6 +142,19 @@ def _target_names(target):
     return set()
 
 
+def _direct_target_names(target):
+    if isinstance(target, ast.Name):
+        return {target.id}
+    if isinstance(target, (ast.List, ast.Tuple)):
+        names = set()
+        for item in target.elts:
+            names.update(_direct_target_names(item))
+        return names
+    if isinstance(target, ast.Starred):
+        return _direct_target_names(target.value)
+    return set()
+
+
 def _root_name(node):
     while True:
         name = _namespace_lookup_name(node)
@@ -1099,11 +1112,17 @@ def _input_types(cls, env, decorator_env):
     for stmt in cls.body:
         mutating_targets = _mutating_call_target_names(stmt)
         observed_targets = _arbitrary_call_observed_names(stmt)
-        if "INPUT_TYPES" in mutating_targets or aliases.intersection(mutating_targets):
-            value = _INVALID
-        if "INPUT_TYPES" in observed_targets or aliases.intersection(observed_targets):
+        input_types_invalidated = (
+            "INPUT_TYPES" in mutating_targets
+            or bool(aliases.intersection(mutating_targets))
+            or "INPUT_TYPES" in observed_targets
+            or bool(aliases.intersection(observed_targets))
+        )
+        if input_types_invalidated:
             value = _INVALID
         if isinstance(stmt, ast.FunctionDef) and stmt.name == "INPUT_TYPES":
+            if input_types_invalidated:
+                continue
             if not _input_types_decorators_are_supported(stmt.decorator_list, classmethod_shadowed):
                 value = _INVALID
                 continue
@@ -1435,6 +1454,139 @@ def _module_dict_alias_invalidated(stmt, aliases):
     return any(name in aliases for name in names)
 
 
+def _namespace_alias_sources(value, aliases):
+    if _namespace_call_function_name(value) is not None:
+        return True
+    if isinstance(value, ast.Name):
+        return value.id in aliases
+    if isinstance(value, (ast.Tuple, ast.List)):
+        return any(_namespace_alias_sources(item, aliases) for item in value.elts)
+    return False
+
+
+def _namespace_alias_subscript_name(node, aliases):
+    if not isinstance(node, ast.Subscript):
+        return None
+    if not isinstance(node.value, ast.Name) or node.value.id not in aliases:
+        return None
+    if isinstance(node.slice, ast.Constant) and isinstance(node.slice.value, str):
+        return node.slice.value
+    return None
+
+
+def _namespace_alias_target_names(target, aliases):
+    name = _namespace_alias_subscript_name(target, aliases)
+    if name is not None:
+        return {name}
+    if isinstance(target, (ast.Tuple, ast.List)):
+        names = set()
+        for item in target.elts:
+            names.update(_namespace_alias_target_names(item, aliases))
+        return names
+    if isinstance(target, ast.Starred):
+        return _namespace_alias_target_names(target.value, aliases)
+    if isinstance(target, (ast.Attribute, ast.Subscript)):
+        return _namespace_alias_target_names(target.value, aliases)
+    return set()
+
+
+def _namespace_alias_mutation_target_names(stmt, aliases):
+    names = set()
+
+    class NamespaceAliasMutationVisitor(ast.NodeVisitor):
+        def _visit_function_definition_expressions(self, node):
+            for decorator in node.decorator_list:
+                self.visit(decorator)
+            self.visit(node.args)
+            if node.returns is not None:
+                self.visit(node.returns)
+            for type_param in getattr(node, "type_params", ()):
+                self.visit(type_param)
+
+        def visit_FunctionDef(self, node):
+            self._visit_function_definition_expressions(node)
+
+        def visit_AsyncFunctionDef(self, node):
+            self._visit_function_definition_expressions(node)
+
+        def visit_ClassDef(self, node):
+            for decorator in node.decorator_list:
+                self.visit(decorator)
+            for base in node.bases:
+                self.visit(base)
+            for keyword in node.keywords:
+                self.visit(keyword.value)
+            for type_param in getattr(node, "type_params", ()):
+                self.visit(type_param)
+            for child in node.body:
+                self.visit(child)
+
+        def visit_Lambda(self, node):
+            self.visit(node.args)
+
+        def visit_Assign(self, node):
+            for target in node.targets:
+                names.update(_namespace_alias_target_names(target, aliases))
+            self.visit(node.value)
+
+        def visit_AnnAssign(self, node):
+            names.update(_namespace_alias_target_names(node.target, aliases))
+            if node.value is not None:
+                self.visit(node.value)
+
+        def visit_AugAssign(self, node):
+            names.update(_namespace_alias_target_names(node.target, aliases))
+            self.visit(node.value)
+
+        def visit_Delete(self, node):
+            for target in node.targets:
+                names.update(_namespace_alias_target_names(target, aliases))
+
+        def visit_Call(self, node):
+            if isinstance(node.func, ast.Attribute):
+                if isinstance(node.func.value, ast.Name) and node.func.value.id in aliases:
+                    if node.func.attr == "update":
+                        for keyword in node.keywords:
+                            names.add(_DYNAMIC_NAMESPACE_MUTATION if keyword.arg is None else keyword.arg)
+                        if node.args or not node.keywords:
+                            names.add(_DYNAMIC_NAMESPACE_MUTATION)
+                    elif node.func.attr in _MUTATING_METHODS:
+                        names.add(_DYNAMIC_NAMESPACE_MUTATION)
+                namespace_name = _namespace_alias_subscript_name(node.func.value, aliases)
+                if namespace_name is not None and node.func.attr in _MUTATING_METHODS:
+                    names.add(namespace_name)
+            self.generic_visit(node)
+
+    NamespaceAliasMutationVisitor().visit(stmt)
+    return names
+
+
+def _update_namespace_aliases(stmt, aliases):
+    direct_names = set()
+    if isinstance(stmt, ast.Assign):
+        for target in stmt.targets:
+            direct_names.update(_direct_target_names(target))
+    elif isinstance(stmt, (ast.AnnAssign, ast.AugAssign)):
+        direct_names.update(_direct_target_names(stmt.target))
+    elif isinstance(stmt, ast.Delete):
+        for target in stmt.targets:
+            direct_names.update(_direct_target_names(target))
+    direct_names.update(_bound_names(stmt))
+    aliases.difference_update(direct_names)
+
+    if isinstance(stmt, ast.Assign) and len(stmt.targets) == 1 and isinstance(stmt.targets[0], ast.Name):
+        if _namespace_alias_sources(stmt.value, aliases):
+            aliases.add(stmt.targets[0].id)
+    elif isinstance(stmt, ast.Assign) and len(stmt.targets) == 1:
+        for target_item, value_item in _unpack_target_value_pairs(stmt.targets[0], stmt.value):
+            target_name = _alias_target_name(target_item)
+            if target_name is not None and _namespace_alias_sources(value_item, aliases):
+                aliases.add(target_name)
+    elif isinstance(stmt, ast.AnnAssign) and isinstance(stmt.target, ast.Name) and stmt.value is not None:
+        if _namespace_alias_sources(stmt.value, aliases):
+            aliases.add(stmt.target.id)
+
+
 def _update_module_dict_aliases(stmt, name, aliases):
     rebound_names = _assignment_target_names(stmt) | _delete_target_names(stmt) | _bound_names(stmt)
     for rebound_name in rebound_names:
@@ -1460,6 +1612,7 @@ def _final_module_dict(tree, name, value_converter, value_invalidated_by_names=N
     class_aliases = {}
     class_attribute_aliases = {}
     module_dict_aliases = {}
+    namespace_aliases = set()
 
     def advance_module_state(stmt):
         _invalidate_class_bindings(
@@ -1470,6 +1623,7 @@ def _final_module_dict(tree, name, value_converter, value_invalidated_by_names=N
         _update_class_aliases(stmt, class_aliases, class_bindings)
         _update_class_attribute_aliases(stmt, class_attribute_aliases, class_aliases, class_bindings)
         _update_module_dict_aliases(stmt, name, module_dict_aliases)
+        _update_namespace_aliases(stmt, namespace_aliases)
 
     for stmt in tree.body:
         class_attr_names = _module_class_attribute_invalidated_names(stmt, class_aliases, class_attribute_aliases)
@@ -1483,6 +1637,8 @@ def _final_module_dict(tree, name, value_converter, value_invalidated_by_names=N
             value = _INVALID
         if _name_invalidated_by(name, _arbitrary_call_observed_names(stmt)):
             value = _INVALID
+        if _name_invalidated_by(name, _namespace_alias_mutation_target_names(stmt, namespace_aliases)):
+            value = _INVALID
         if _module_dict_alias_invalidated(stmt, module_dict_aliases):
             value = _INVALID
         if isinstance(stmt, ast.Assign):